Unemployment is one of the major problems of our country.
He has two major blockages in the blood vessels of his heart.
My grandfather underwent major surgery last year.
The change in climate is the major reason for the destruction around the world.
Mobile and iPods have played a major role in our social upheaval.
Water Wastage is another major cause of water crisis.
History has been a great motivating factor for all major events that have occurred in the world.
Self-esteem is a major component in determining success or failure.
The major source of air pollution in the cities is the heavy traffic on the roads.
Environment plays a major role in our physical health.